The expression of MfpA protein of Mycobacterium tuberculosis causes resistance to the family of fluoroquinolone antibiotics. A tail-to-tail homodimer of MfpA shown in this movie produces the right-handed quadrilateral beta helix that exhibits size, shape, and electrostatic similarity to a 30-base pair segment of B-form DNA. Thus, it seems that this protein binds to gyrase and inhibits its activity by mimicking DNA. [Ref. S. Hedge et al. Science vol 308, 1480 (2005)]